Elektrostimulacija u ELF području

Repac, Filip

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master's thesis

Elektrostimulacija u ELF području

odziv neurona na duboku stimulaciju mozga (DBS) i na nenamjernu izloženost elektromagnetskom polju

2022. urn:nbn:hr:179:559123

Repac, Filip

University of Split
Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture
Department of Electronics and Computing

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APA 6th Edition

Repac, F. (2022). Elektrostimulacija u ELF području : odziv neurona na duboku stimulaciju mozga (DBS) i na nenamjernu izloženost elektromagnetskom polju (Master's thesis). Split: University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture. Retrieved from https://urn.nsk.hr/urn:nbn:hr:179:559123

MLA 8th Edition

Repac, Filip. "Elektrostimulacija u ELF području : odziv neurona na duboku stimulaciju mozga (DBS) i na nenamjernu izloženost elektromagnetskom polju." Master's thesis, University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, 2022. https://urn.nsk.hr/urn:nbn:hr:179:559123

Chicago 17th Edition

Harvard

Repac, F. (2022). 'Elektrostimulacija u ELF području : odziv neurona na duboku stimulaciju mozga (DBS) i na nenamjernu izloženost elektromagnetskom polju', Master's thesis, University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, accessed 14 November 2024, https://urn.nsk.hr/urn:nbn:hr:179:559123

Vancouver

Repac F. Elektrostimulacija u ELF području : odziv neurona na duboku stimulaciju mozga (DBS) i na nenamjernu izloženost elektromagnetskom polju [Master's thesis]. Split: University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture; 2022 [cited 2024 November 14] Available at: https://urn.nsk.hr/urn:nbn:hr:179:559123

IEEE

F. Repac, "Elektrostimulacija u ELF području : odziv neurona na duboku stimulaciju mozga (DBS) i na nenamjernu izloženost elektromagnetskom polju", Master's thesis, University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, Split, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:179:559123

Cite this item: https://urn.nsk.hr/urn:nbn:hr:179:559123

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Title	Elektrostimulacija u ELF području : odziv neurona na duboku stimulaciju mozga (DBS) i na nenamjernu izloženost elektromagnetskom polju
Title (english)	Electrostimulation in the ELF range : neuron response to deep brain stimulation (DBS) and to inadvertent EMF exposure
Author	Filip Repac
Mentor	Antonio Šarolić https://orcid.org/0000-0001-7941-1977 (mentor)
Granter	University of Split Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture (Department of Electronics and Computing) Split
Defense date and country	2022-09-21, Croatia
Scientific / art field, discipline and subdiscipline	TECHNICAL SCIENCES Electrical Engineering Telecommunications and Informatics
Abstract	Cilj rada bio je proučiti i predočiti elektrofiziologiju i funkcioniranje neurona, njegove membrane i sinapsi te mehanizme širenja signala, zajedno s popratnim jednadžbama i modelima membrane. Prikazani su i alati za računalnu simulaciju neurona: NEURON i SENN. NEURON je obrađen samo teoretski, dok je SENN i praktično korišten te mu je detaljno objašnjen princip rada. Fokus rada bio je na elektrostimulaciji u ELF području koja je u radu obrađena s dva aspekta: medicinska primjena za duboku stimulaciju mozga (DBS) te djelovanje nenamjernog izlaganja ljudi elektromagnetskom polju. Provedena je i prikazana simulacija podražljivosti neurona računalnim alatom SENN, gdje je prikazan odziv na nekoliko vrsta signala. Prikazane su SF i SD krivulja za signal DBS-a. Pokazan je učinak blokiranja živca kontinuiranim sinusnim signalom velike amplitude. Na kraju, prikazan je i inhibicijski učinak vanjskog sinusnog električnog polja frekvencije 50 Hz na slijedove fizioloških akcijskih potencijala. Iz rezultata se može zaključiti da čak i pri vanjskom sinusnom elektromagnetskom polju od samo 20% amplitude iznosa praga dolazi do inhibicije fizioloških akcijskih potencijala.
Abstract (english)	The aim of this master thesis was to study and to present the electrophysiology and functioning of a neuron, its membrane and synapses, and to describe the mechanisms of signal propagation, along with the matching equations and membrane models. Neuron computer simulation tools were presented: NEURON and SENN. NEURON was only explained theoretically, while SENN was used experimentally and its work principles were explained in details. Focus of the thesis was on electrostimulation in ELF range, which was considered from two aspects: medical application for deep brain stimulation (DBS), and the effect of unintentional human exposure to electromagnetic fields. Simulation of neuron excitability using SENN was performed, where responses to several stimuli are presented. SF and SD curves are shown for DBS signals. The effect of nerve blocking by continuous high-amplitude sinusoid signal was demonstrated. Finally, the inhibition effect of the external sinusoidal 50 Hz electric field on the physiological signaling was demonstrated. The results support a conclusion that the external electric field stimulation with only 20% of the amplitude of the excitability threshold results with the inhibition of the physiological action potentials.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:179:559123
Study programme	Title: Communications and Information Technology Study programme type: university Study level: graduate Academic / professional title: magistar/magistra inženjer/inženjerka komunikacjske i informacijske tehnologije (magistar/magistra inženjer/inženjerka komunikacjske i informacijske tehnologije)
Type of resource	Text
File origin	Born digital
Access conditions	Access restricted to authenticated users
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Created on	2023-06-21 11:29:56