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doctoral thesis
Permittivity Measurement of Biological Tissues and Open-ended Coaxial Probe Measurement Method Analysis
2024. urn:nbn:hr:179:778854
Matković, Anđela
University of Split
Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture

Cite this document

Matković, A. (2024). Permittivity Measurement of Biological Tissues and Open-ended Coaxial Probe Measurement Method Analysis (Doctoral thesis). Split: University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture. Retrieved from https://urn.nsk.hr/urn:nbn:hr:179:778854

Matković, Anđela. "Permittivity Measurement of Biological Tissues and Open-ended Coaxial Probe Measurement Method Analysis." Doctoral thesis, University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, 2024. https://urn.nsk.hr/urn:nbn:hr:179:778854

Matković, Anđela. "Permittivity Measurement of Biological Tissues and Open-ended Coaxial Probe Measurement Method Analysis." Doctoral thesis, University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, 2024. https://urn.nsk.hr/urn:nbn:hr:179:778854

Matković, A. (2024). 'Permittivity Measurement of Biological Tissues and Open-ended Coaxial Probe Measurement Method Analysis', Doctoral thesis, University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, accessed 24 October 2024, https://urn.nsk.hr/urn:nbn:hr:179:778854

Matković A. Permittivity Measurement of Biological Tissues and Open-ended Coaxial Probe Measurement Method Analysis [Doctoral thesis]. Split: University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture; 2024 [cited 2024 October 24] Available at: https://urn.nsk.hr/urn:nbn:hr:179:778854

A. Matković, "Permittivity Measurement of Biological Tissues and Open-ended Coaxial Probe Measurement Method Analysis", Doctoral thesis, University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:179:778854

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Metadata
TitlePermittivity Measurement of Biological Tissues and Open-ended Coaxial Probe Measurement Method Analysis
Title (english)Mjerenje permitivnosti bioloških tkiva i analiza metode mjerenja koaksijalnom sondom s otvorenim krajem
AuthorAnđela Matković
MentorAntonio Šarolić (mentor)
Committee memberIvan Marinović (predsjednik povjerenstva)
Committee memberZoran Blažević (član povjerenstva)
Committee memberMaja Škiljo (član povjerenstva)
Committee memberDavor Bonefačić (član povjerenstva)
GranterUniversity of Split
Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture
Split
Defense date and country2024, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Electrical Engineering
Electronics
Universal decimal classification
(UDC)		621.3 - Electrical engineering
Abstract
Ovaj doktorski rad objedinjuje studije o metodi mjerenja permitivnosti koaksijalnom sondom s otvorenim krajem, s naglaskom na njenu primjenu na biološka tkiva u mikrovalnom frekvencijskom području. Mjerna studija provedena je na ex vivo uzorcima ljudskog goveđeg i svinjskog tkiva, što je rezultiralo razvojem Cole-Cole modela permitivnosti izmjerenih tkiva mozga za svaku vrstu pojedinačno. Studija je također ukazala na varijacije permitivnosti unutar i između vrsta te utjecaj propadanja tkiva na permitivnost. Studija o očuvanju permitivnosti tkiva istraživala je utjecaj procesa smrzavanja i odmrzavanja na permitivnost goveđih tkiva, što je uključivalo tkiva mozga, mišić i jetru. Statistička značajnost promjene permitivnosti zbog ciklusa smrzavanja i odmrzavanja ovisila je o frekvencijskom rasponu i ispitivanom tkivu. Zbog uočene složenosti mjerenja permitivnosti bioloških tkiva i njenog očuvanja, razvijen je opsežan model koji omogućuje analizu cjelokupnog mjernog procesa. On obuhvaća računalno elektromagnetsko modeliranje, simulacije i naknadne izračune korištenjem jednostavnog kapacitivnog modela koji je potvrđen mjerenjima. Cjeloviti model je rezultirao zanemarivim pogreškama i, unatoč manjim nedostacima na nižim frekvencijama, simulacije su dale točne rezultate, ponajviše za fiziološku otopinu, čija permitivnost je približna permitivnosti bioloških materijala s visokim sadržajem vode. Rezultati ovih studija unapređuju postojeće znanje o dielektričnim svojstvima bioloških tkiva, posebice tkiva ljudskog mozga, i pružaju važne spoznaje o metodi mjerenja koaksijalnom sondom s otvorenim krajem.
Abstract (english)
This doctoral thesis presents the studies of the open-ended coaxial probe permittivity measurement method, with the emphasis on its application to biological tissues in the microwave frequency range. A measurement study was conducted on human, bovine, and porcine ex vivo samples, resulting in Cole-Cole permittivity models of the measured brain tissues for each species. The study also revealed intra- and interspecies variations and the impact of tissue degradation. The study on tissue permittivity preservation investigated the effect of freezing and thawing on the permittivity of bovine tissues, including brain tissues, muscle, and liver. The statistical significance of the permittivity change due to a freeze-thaw cycle was dependent on the frequency range and the tissue investigated. Due to the observed complexity of measurement of biological tissue permittivity and preservation thereof, a comprehensive model was developed to enable the analysis of the entire measurement process. This encompassed computer electromagnetic modeling, simulations, and postprocessing calculations using a simple capacitive-load model which was validated by measurements. The entire model produced negligible errors and, despite minor deficiencies at lower frequencies, the simulations yielded accurate results, especially for physiological saline, which approximates high water content biological materials. The outcomes of these studies enhance the existing knowledge on dielectric properties of biological tissues, particularly human brain tissues, and provide valuable insights into the open-ended coaxial probe measurement method
Keywords
Keywords (english)
Languageenglish
URN:NBNurn:nbn:hr:179:778854
Promotion2024
Study programmeTitle: Electrical Engineering and Information Technology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje tehničkih znanosti, polje elektrotehnika (doktor/doktorica znanosti, područje tehničkih znanosti, polje elektrotehnika)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-07-12 11:51:14